Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC061
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-20 13:22
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment MADOPAR 250MG 3X1\4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.66 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.66 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 23, 'TN': 17, 'TP': 19, 'FP': 13}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 24, 'TN': 20, 'TP': 18, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 35, 'TN': 29, 'TP': 7, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 3, 'TN': 3, 'TP': 39, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 5.348
timePerCircleCoV 0.251796
timePerCircleSlope -0.0189026
meanError 2.10731
tremorFreq 5.46875
tremorRelPower 19.5765
tremorGyroAmpMean 0.0818277
tremorGyroAmpSlope -0.0104068
tremorGyroAmpCoV 0.99703
tremorCoordAmpMean 0.0764705
tremorCoordAmpSlope -0.00711913
tremorCoordAmpCoV 0.293668
tremorAccAmpMean 0.0609239
tremorAccAmpSlope -0.00639729
tremorAccAmpCoV 0.300882
tremorPcRelVar 0.604428
tremorPcX 0.166715
tremorPcY -0.986005

Circle Segment 1

Duration 5.32 s, Accuracy Estimate 1.976 (lower is better)

Circle Segment 2

Duration 4.64 s, Accuracy Estimate 2.003 (lower is better)

Circle Segment 3

Duration 4.52 s, Accuracy Estimate 2.228 (lower is better)

Circle Segment 4

Duration 6.16 s, Accuracy Estimate 1.627 (lower is better)

Circle Segment 5

Duration 6.16 s, Accuracy Estimate 1.45 (lower is better)

Circle Segment 6

Duration 8.16 s, Accuracy Estimate 2.386 (lower is better)

Circle Segment 7

Duration 5.92 s, Accuracy Estimate 2.286 (lower is better)

Circle Segment 8

Duration 4.76 s, Accuracy Estimate 1.995 (lower is better)

Circle Segment 9

Duration 4.68 s, Accuracy Estimate 1.942 (lower is better)

Circle Segment 10

Duration 3.16 s, Accuracy Estimate 3.18 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 8.764
timePerSpiralCoV 0.230542
timePerSpiralSlope 0.00528332
meanError 2.75119
tremorFreq 6.93359
tremorRelPower 21.2216
tremorGyroAmpMean 0.0519138
tremorGyroAmpSlope 0.00438667
tremorGyroAmpCoV 0.498855
tremorCoordAmpMean 0.0964387
tremorCoordAmpSlope 0.00385895
tremorCoordAmpCoV 0.406508
tremorAccAmpMean 0.0754176
tremorAccAmpSlope 0.00688947
tremorAccAmpCoV 0.422688
tremorPcRelVar 0.578133
tremorPcX 0.179034
tremorPcY 0.983843

Spiral Segment 1

Duration 9.8 s, Accuracy Estimate 2.331 (lower is better)

Spiral Segment 2

Duration 6.24 s, Accuracy Estimate 3.625 (lower is better)

Spiral Segment 3

Duration 9.96 s, Accuracy Estimate 2.266 (lower is better)

Spiral Segment 4

Duration 5.8 s, Accuracy Estimate 3.568 (lower is better)

Spiral Segment 5

Duration 12.36 s, Accuracy Estimate 2.465 (lower is better)

Spiral Segment 6

Duration 7.88 s, Accuracy Estimate 2.414 (lower is better)

Spiral Segment 7

Duration 10.16 s, Accuracy Estimate 2.525 (lower is better)

Spiral Segment 8

Duration 7.2 s, Accuracy Estimate 3.057 (lower is better)

Spiral Segment 9

Duration 9.72 s, Accuracy Estimate 2.969 (lower is better)

Spiral Segment 10

Duration 8.52 s, Accuracy Estimate 2.292 (lower is better)

Elel

eDurationMean 0.248548
eDurationStd 0.0603765
eDurationStdnorm 0.242917
eDurationMedian 0.24
eDurationQuartdelta 0.0475
eDurationQuartdeltanorm 0.197917
eDurationKurt 3.48232
eDurationTrenddiff -0.01
eDurationTrendratio 0.958333
eWidthMean 4.17426
eWidthStd 1.62328
eWidthStdnorm 0.388878
eWidthMedian 3.744
eWidthQuartdelta 1.6965
eWidthQuartdeltanorm 0.453125
eWidthKurt 4.33514
eWidthTrenddiff -0.117
eWidthTrendratio 0.969697
eHeightMean 12.6888
eHeightStd 4.16591
eHeightStdnorm 0.328313
eHeightMedian 11.934
eHeightQuartdelta 7.254
eHeightQuartdeltanorm 0.607843
eHeightKurt 1.89694
eHeightTrenddiff 1.287
eHeightTrendratio 1.11702
eAspectMean 0.34843
eAspectStd 0.129432
eAspectStdnorm 0.371471
eAspectMedian 0.333333
eAspectQuartdelta 0.164878
eAspectQuartdeltanorm 0.494634
eAspectKurt 3.60561
eAspectTrenddiff -0.0254902
eAspectTrendratio 0.928962
eSlantMean -0.294929
eSlantStd 0.24585
eSlantStdnorm -0.833592
eSlantMedian -0.333333
eSlantQuartdelta 0.315868
eSlantQuartdeltanorm -0.947603
eSlantKurt 3.49133
eSlantTrenddiff 0.0724638
eRtopMean 0.716684
eRtopStd 0.136796
eRtopStdnorm 0.190873
eRtopMedian 0.692308
eRtopQuartdelta 0.203984
eRtopQuartdeltanorm 0.294643
eRtopKurt 1.91979
eRtopTrenddiff 0.0135747
eRbotMean 1.72564
eRbotStd 0.801502
eRbotStdnorm 0.464468
eRbotMedian 1.6875
eRbotQuartdelta 0.840203
eRbotQuartdeltanorm 0.497898
eRbotKurt 3.94653
eRbotTrenddiff -0.129808
eRrightMean 0.900166
eRrightStd 0.088658
eRrightStdnorm 0.0984907
eRrightMedian 0.923077
eRrightQuartdelta 0.0973554
eRrightQuartdeltanorm 0.105468
eRrightKurt 3.26468
eRrightTrenddiff -0.0308943
eRleftMean 0.518219
eRleftStd 0.133914
eRleftStdnorm 0.258412
eRleftMedian 0.518072
eRleftQuartdelta 0.175106
eRleftQuartdeltanorm 0.337994
eRleftKurt 4.29397
eRleftTrenddiff -0.0223881
lDurationMean 0.268846
lDurationStd 0.0313467
lDurationStdnorm 0.116597
lDurationMedian 0.265
lDurationQuartdelta 0.045
lDurationQuartdeltanorm 0.169811
lDurationKurt 1.9878
lDurationTrenddiff -5.68434e-14
lDurationTrendratio 1
lWidthMean 7.9065
lWidthStd 1.80322
lWidthStdnorm 0.228068
lWidthMedian 8.073
lWidthQuartdelta 2.574
lWidthQuartdeltanorm 0.318841
lWidthKurt 3.07902
lWidthTrenddiff 1.287
lWidthTrendratio 1.18333
lHeightMean 29.6595
lHeightStd 3.88599
lHeightStdnorm 0.13102
lHeightMedian 29.835
lHeightQuartdelta 5.148
lHeightQuartdeltanorm 0.172549
lHeightKurt 3.30514
lHeightTrenddiff -0.936
lHeightTrendratio 0.968992
lAspectMean 0.269354
lAspectStd 0.0634404
lAspectStdnorm 0.235528
lAspectMedian 0.268756
lAspectQuartdelta 0.0897357
lAspectQuartdeltanorm 0.333893
lAspectKurt 3.06437
lAspectTrenddiff 0.0638706
lAspectTrendratio 1.27251
lSlantMean -0.0710075
lSlantStd 0.0881346
lSlantStdnorm -1.2412
lSlantMedian -0.0688829
lSlantQuartdelta 0.109026
lSlantQuartdeltanorm -1.58278
lSlantKurt 4.04468
lSlantTrenddiff 0.089792
lRtopMean 0.763458
lRtopStd 0.0969072
lRtopStdnorm 0.126932
lRtopMedian 0.768693
lRtopQuartdelta 0.151066
lRtopQuartdeltanorm 0.196523
lRtopKurt 3.27477
lRtopTrenddiff 0.113522
lRbotMean 1.07135
lRbotStd 0.315105
lRbotStdnorm 0.294119
lRbotMedian 0.997991
lRbotQuartdelta 0.296084
lRbotQuartdeltanorm 0.29668
lRbotKurt 4.24031
lRbotTrenddiff -0.207882
lRrightMean 0.850623
lRrightStd 0.0883321
lRrightStdnorm 0.103844
lRrightMedian 0.873513
lRrightQuartdelta 0.109234
lRrightQuartdeltanorm 0.125052
lRrightKurt 2.97283
lRrightTrenddiff 0.102039
lRleftMean 0.454813
lRleftStd 0.102709
lRleftStdnorm 0.225826
lRleftMedian 0.441656
lRleftQuartdelta 0.151579
lRleftQuartdeltanorm 0.343206
lRleftKurt 2.20306
lRleftTrenddiff -0.142767

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.796789
sumTouchScores 17.5294
meanMovementTime 0.89881
numTouches 22
undershootPercentage 0
overshootPercentage 22.7273

FITTS Long Modified

meanTouchScore 0.788475
sumTouchScores 9.4617
meanMovementTime 1.41727
numTouches 12
undershootPercentage 8.33333
overshootPercentage 25

ZigZag

numZigzags 5
timePerZigzagMean 18.144
timePerZigzagCoV 0.409129
timePerZigzagSlope -0.243607
meanError 2.83632
tremorFreq 7.03125
tremorRelPower 24.7682
tremorGyroAmpMean 0.0364484
tremorGyroAmpSlope 0.0143148
tremorGyroAmpCoV 0.68897
tremorCoordAmpMean 0.0726695
tremorCoordAmpSlope 0.011835
tremorCoordAmpCoV 0.554675
tremorAccAmpMean 0.0584723
tremorAccAmpSlope 0.00865045
tremorAccAmpCoV 0.556383
tremorPcRelVar 0.792517
tremorPcX 0.0317088
tremorPcY -0.999497

ZigZag Segment 1

Duration 26.24 s, Accuracy Estimate 2.059 (lower is better)

ZigZag Segment 2

Duration 21.96 s, Accuracy Estimate 2.323 (lower is better)

ZigZag Segment 3

Duration 18.6 s, Accuracy Estimate 2.423 (lower is better)

ZigZag Segment 4

Duration 17.6 s, Accuracy Estimate 3.145 (lower is better)

ZigZag Segment 5

Duration 6.32 s, Accuracy Estimate 4.232 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 10.496
timePerZigzagCoV 0.153024
timePerZigzagSlope -0.0121951
zigzagHeightMean 61.5015
zigzagHeightCoV 0.0470248
zigzagHeightSlope -0.0123002
meanError 0.0343392
tremorFreq 5.66406
tremorRelPower 24.9433
tremorGyroAmpMean 0.0779658
tremorGyroAmpSlope 0.00129349
tremorGyroAmpCoV 0.609234
tremorCoordAmpMean 0.108098
tremorCoordAmpSlope 0.00334872
tremorCoordAmpCoV 0.375667
tremorAccAmpMean 0.120104
tremorAccAmpSlope 0.00431579
tremorAccAmpCoV 0.252168
tremorPcRelVar 0.775665
tremorPcX 0.536103
tremorPcY -0.844152

ZigZag Offset Segment 1

Duration 10.56 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 2

Duration 11.08 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 3

Duration 11.52 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 4

Duration 7.72 s, Accuracy Estimate 0.037 (lower is better)

ZigZag Offset Segment 5

Duration 11.6 s, Accuracy Estimate 0.054 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.8}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.66}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.040595000005544835}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.5393957966597649}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44192353540889495}